Back up your savedata.bin and config.ini before any tweak. Some mods break if you have the Ultimate HD Texture Pack enabled.
: Originally stripped from the PC release, RE5 Tweaks (often used alongside Maluc's Split Screen logic) enables local co-op on a single machine. This allows two players to play with their own inventories and HUDs, just like on consoles. re5 tweaks
Guide :: Resident Evil 5 Quality of Life Fixes - Steam Community Back up your savedata