You cannot run a native PS2 ISO directly on PPSSPP because PPSSPP only emulates the PlayStation Portable. However, tech-savvy users have created "PSP Remasters" or compressed CSO files (Compressed ISO) that can be converted.
: To play God Hand on Android or PC, users typically use AetherSX2 or Dolphin (if playing the Wii version via emulation), which are built to handle PS2 or GameCube/Wii titles. God Hand Ppsspp Zip File Download 200mb
Since you’re emulating a PS2, you’ll need a device with at least 2GB of RAM and a decent processor (Snapdragon recommended) to avoid lag. Final Verdict You cannot run a native PS2 ISO directly