Right-click the launcher -> Run as Administrator . Why? Because the portable app needs to register temporary "virtual registry" keys. If you don't run as admin on the first launch, picture box imports might fail.
: It does not leave behind temporary files or registry entries on the host computer, making it ideal for designers working across multiple workstations. QuarkXPress 9.2.0.2 Portable
: Preferred by long-time users who find modern Creative Cloud or newer Quark interfaces cluttered. Security Risks Right-click the launcher -> Run as Administrator